What is Microarray?
Variations in DNA can result to various conditions or phenotypes. Single nucleotide polymorphisms (or SNPs) are sequences that occur when a nucleotide in the DNA differ between paired chromosomes or biological species.
Microarray is a technique used to detect multiple target sequences in an organism’s genome. It can genotype multiple regions in the DNA (deoxyribonucleic acid), can be used to measure expression levels of large number of genes using RNA (ribonucleic acid) simultaneously, and it can also detect changes in DNA methylation.
These applications can be used to: look for biomarkers associated with certain conditions; seek molecular targets for manipulation; and explain molecular processes related to a trait.
Currently, the Microarray Core Laboratory has on-going projects on the following diseases:
• Cardiovascular Diseases: Coronary Artery Diseases, Hypertension, Dyslipidemia
• Type 2 Diabetes Mellitus
• Systemic Lupus Erythematosus
The Microarray Technology
BeadChips HiScan™ Reader
The HiScan™ Reader functions as a high-speed, precision imaging scanner for Illumina sequencing and microarray-based analyses. It is a high-resolution optical imaging instrument that uses red and green lasers to detect fluorescence information on BeadChips.
Contact the Microarray Core Laboratory for more information:
The UP-NIH Microarray Core Laboratory
Institute of Human Genetics
The National Institutes of Health
2nd floor, 620 Pedro Gil St., Ermita, Manila 1000
Telephone: 310-1780 local 116